Nitrososynthase-Triggered Oxidative Carbon–Carbon Bond Cleavage in Baumycin Biosynthesis

Biocatalytic oxidative C=C bond cleavage and C-C bond formation studies on phenolic derivatives in ionic liquid media

Oxidative C-C bond cleavage of N-alkoxycarbonylated cyclic amines by sodium nitrite in trifluoroacetic acid

Oxidative carbon-carbon bond cleavage of N-alkoxycarbonylated cyclic amines was accomplished by NaNO2 in TFA to afford ω-amino carboxylic acid in high yield. Optically active 3-hydroxypiperidine derivatives and 3-pipecolinate, were converted to enantiomerically pure (R)-4-amino-3-hydroxybutanoic acid (GABOB) and (S)-2-pyrrolidone-4-carboxylate, respectively. It is well known that trifluoroaceti...

Synthesis of Zinc Dimethyldithiocarbamate by Reductive Disulfide Bond Cleavage of Tetramethylthiuram Disulfide in Presence of Zn2+

The zinc(II) complex [Zn2(dmdtc)2(μ-dmdtc)2] has been synthesized directly from thiram ligand, containing a disulfide bond {dmdtc = N,N-dimethyldithiocarbamate; thiram = N,N-tetramethylthiuram disulfide}, and characterized by elemental analysis and spectroscopic methods. Surprisingly thiram, undergoes a reductive disulfide bond scission upon reaction with Zn2+ in methanolic media to give the [Z...

Optimization of Nonenzymatic Microwave D-Cleavage and Disulfide Bond Cleavage

A nonenzymatic digestion technique allows proteins to be well suited for collision-induced dissociation tandem mass spectrometry. This method utilizes microwaves and Dithiothreitol (DTT) to selectively cleave at aspartic acid (D) and disulfide bonds. This microwave digestion technique is reproducible and produces peptides with a shortened sequence length. Insulin I is used in this study to opti...

Non-oxidative vanadium-catalyzed C-O bond cleavage: application to degradation of lignin model compounds.

Lignocellulosic biomass has recently received great interest as a renewable source of fuel and chemicals. Among the three major components of non-edible lignocellulose (cellulose, hemicellulose, and lignin), extensive efforts have been made to convert cellulose into ethanol and other biofuels. In contrast, research on the conversion of lignin has been limited to its removal from biomass either ...